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Behind every new drug or vaccine is a journey that ultimately transformed medicine. People with sickle cell disease — marked by malformed, sickle-shaped red blood cells that can aggregate and block small vessels — experience excruciating pain crises, tissue and organ damage, and shortened life expectancy. Until recently, treatment options have been limited. The lab of Stuart Orkin at Harvard Medical School, Boston Children’s Hospital, and Dana-Farber Cancer Institute made crucial discoveries tha
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